intravenous amiodarone for acute pharmacological
results for this questionCan amiodarone be used for atrial fibrillation?Can amiodarone be used for atrial fibrillation?Although the U.S.Food and Drug Administration (FDA) has labeled amiodarone only for the treatment of life-threatening ventricular arrhythmias,the drug also is used to treat atrial fibrillation.Because of the complexity and widespread use of this agent,other treatment decisions often are affected.Amiodarone Guidelines for Use and Monitoring - American results for this questionCan amiodarone cause liver failure?Can amiodarone cause liver failure?We report an unusual case of acute liver and renal failure within 24 hours of initiation of intravenous (IV) amiodarone.Despite wide popularity and efficacy of amiodarone in the treatment of various kinds of cardiac arrhythmias,little is understood about the mechanisms by which IV amiodarone can lead to acute liver and renal failure.Acute Liver and Renal Failure A Rare Adverse Effect results for this questionFeedbackIntravenous amiodarone for acute pharmacological
use of conventional doses of IV amiodarone for acute conversion in the ED.High dose IV or combined IV and oral administration may be effective as early as 8 hours in patients with recent-onset AF of <48 hour duration in patients without contraindications to these high dose regimens.There are
results for this questionWhat is Amiodarone IV?What is Amiodarone IV?Introduction Amiodarone is a class III antiarrhythmic drug highly effective against a wide spectrum of ventricular tachyarrhythmias.We report an unusual case of acute liver and renal failure within 24 hours of initiation of intravenous (IV) amiodarone.Acute Liver and Renal Failure A Rare Adverse Effect Acute Liver and Renal Failure A Rare Adverse Effect
AbstractIntroductionCase SummaryDiscussionAdditional PointsAmiodarone is an antiarrhythmic drug which is highly effective against a wide spectrum of ventricular tachyarrhythmias making it irreplaceable in certain group of patients.We report an unusual case of acute liver and renal failure within 24 hours of initiation of intravenous (IV) amiodarone which resolved after stopping the medication.The mechanism of acute liver and renal toxicity is not clearly known but is believed to be secondary to amiodarone induced (relative) hypotension,idiosyncratic reaction to the drSee more on hindawiCited by 5Publish Year 2016Author Robin Paudel,Prerna Dogra,Saurav Suman,Saurav Acharya,Jyoti MattaAcute Hemodynamic Effects of Intravenous Amiodarone in The acute hemodynamic effects of intravenous amiodarone (Cordarone injectable; Labaz) were studied during cardiac catheterization in 16 male patients with coronary artery disease (age range,3864 years mean,53 years).Amiodarone was administered as a bolus atAcute amiodarone toxicity due to an administration error Jun 25,2009·Acute amiodarone toxicity due to an administration error could excipient be responsible? Amiodarone is widely used for ventricular and supraventricular tachyarrythmia and is a relatively safe choice of drug,particularly in its enteral form in paediatric patients,because of its low negative inotropic action. mostly dose and treatment
Request PDF Acute cardiodepressant effects induced by bolus intravenous administration of amiodarone in rabbits Amiodarone is a potent anti-arrhythmic with a large pharmacologicalAmiodarone (Professional Patient Advice) - DrugsOct 02,2020·Note Although amiodarone may slow ventricular response,the use of amiodarone (both IV and oral) is not particularly effective for cardioversion of atrial fibrillation to normal sinus rhythm as compared to other antiarrhythmics (eg,flecainide).Various IV and oral regimens have been described and may be used clinically.Amiodarone C25H29I2NO3 - PubChemAmiodarone is an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities.As a class III antiarrhythmic agent,amiodarone blocks the myocardial calcium,potassium and sodium channels in cardiac tissue,resulting in prolongation of the cardiac action potential and refractory period.In addition,this agent inhibits alpha- and beta-adrenergic receptors,resulting in a
When used for acute therapy,intravenous amiodarone also has proarrhythmia potential.In the three randomized trials that have examined intravenous amiodarone for management of refractory ventricular arrhythmias,the incidence of new-onset torsade de pointes has been 0.51.5% during a 24-Cited by 110Publish Year 2003Author Ijaz A.Khan,Nirav J.Mehta,Ramesh M.GowdaAmiodarone Guidelines for Use and Monitoring - American Medical usesChemistryInteractionsPharmacologyMechanism of actionAnalysisResearchAdverse effectsEpidemiologyDiagnosisTreatmentRisksSide effectsContraindicationsPrognosisUsageSelected publicationsAmiodarone is a potent antiarrhythmic agent that is used to treat ventricular arrhythmias and atrial fibrillation.The drug prevents the recurrence of life-threatening ventricular arrhythmias and produces a modest reduction of sudden deaths in high-risk patients.Amiodarone is more effective than sotalol or propafenone in preventing recurrent atrial fibrillation in patients for whom a rhythm-control strategy is chosen.When long-term amSee more on aafpCited by 169Publish Year 2003Author Lyle A.SiddowayPublished May 15,2020Cordarone IV (Amiodarone Intravenous) Uses,Dosage,Side Mar 04,2021·Cordarone Intravenous (Cordarone I.V.) contains amiodarone HCl (C 25 H 29 I 2 NO 3 HCl),a class III antiarrhythmic drug.Amiodarone HCl is (2-butyl-3-benzofuranyl) [4- [2- (diethylamino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride.Amiodarone HCl has the following structural formula:Cited by 113Publish Year 1995Author Xiao-Jun Du,Murray D.Esler,Anthony M.DartProcainamide Versus Amiodarone for Stable Ventricular Jun 14,2019·Source Ortiz M,Alfonso M,Arribas F,et al.Randomized comparison of intravenous procainamide vs.intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia the PROCAMIO study.Eur Heart J 2017;38:132935.Study Popluation 74 adults with hemodynamically stable,wide-QRS tachycardia.Efficacy Endpoints Pharmacologic conversion to baseline rhythm
Cited by 11Publish Year 2005Author V Tuseth,H J Jaatun,K DicksteinPharmacological cardioversion of recent onset atrial
Aug 01,2004·Amiodarone has been used both intravenously and orally for cardioversion of the recent-onset atrial fibrillation.8 Intravenous amiodarone has been used as a bolus only or as a bolus followed by a continuous intravenous infusion until conversion or up to 24 h.Cited by 14Publish Year 2009Author Silvana Masi,Stéphan Clément de Cléty,Christine Anslot,Thierry DetailleSympatholytic Action of Intravenous Amiodarone in the Rat Background Amiodarone is a commonly used antiarrhythmic agent with complex pharmacological effects.Although ventricular arrhythmias can be suppressed soon after intravenous amiodarone,the mechanisms responsible for this action are unclear.Cited by 19Publish Year 1985Author P.Holt,J.C.P.Crick,D.W.Davies,P.CurryIntravenous amiodarone in acute anterior myocardial A randomized,single-blind controlled study intended to assess the potential benefits of intravenous amiodarone in anterior myocardial infarction is presented.Three hundred nineteen patients entered the study,159 received amiodarone infusion,and 160 received glucose-insulinpotassium (GIK) infusion.
Cited by 1Publish Year 2016Author Malcolm C.Finlay,Mark Specterman,Richard J.SchillingAcute Electrophysiologic Effects of Intravenous Amiodarone
In summary,acute IV administration of amiodarone to normal volunteers results in significant prolongation of both A-H and H-V intervals,both in the rested and stimulated state.These electrophysiological effects are not accompanied by biochemical evidence of a sympatholytic action nor by hemodynamic changes suggestive of an effect on the sympathetic nervous system,either at rest or with sympathetic activation.Cited by 22Publish Year 1997Author Jeffrey R.BalserUpToDateNoc M,Stajer D,Horvat M.Intravenous amiodarone versus verapamil for acute conversion of paroxysmal atrial fibrillation to sinus rhythm.Am J Cardiol 1990; 65:679.Galve E,Rius T,Ballester R,et al.Intravenous amiodarone in treatment of recent-onset atrial fibrillation results of a randomized,controlled study.J Am Coll Cardiol 1996; 27 Cited by 3Publish Year 1989Author Raffaele Greco,Doriana D'Alterio,Mario Schiattarella,Benito Musto,Simona Wolff,Angelo Sabato BoThe Use of Intravenous Amiodarone in the AcuteThe Use of Intravenous Amiodarone in the Acute Therapy of Life-Threatdning Tachyarrhythmias Alan Kadish and Fred Morady 0 VER THE PAST several years oral amioda- rone has been shown to be effective for a wide variety of supraventricular and ventricular arrhythmias.- A unique aspect of amiodarone
Cited by 50Publish Year 1998Author Edgar R Gonzalez,Barbara S Kannewurf,Joseph P OrnatoAcute low back pain during intravenous administration of
Feb 15,2005·Amiodarone is an antiarrhythmic drug,available for oral and parenteral administration,that exerts class III activity and to a lesser degree class I,II,and IV activities ,.Accumulating evidence suggests that amiodarone represents an effective agent for pharmacological cardioversion of recent-onset atrial fibrillation (AF) ,,.We report on two AF patients who experienced an acute devastatingCited by 5Publish Year 2002Author Richard S.SlavikIntravenous amiodarone for acute pharmacological darone for acute conversion in the ED.High dose IV or combined IV and oral administration may be effective as early as 8 hours in patients with recent-onset AF of 48 hour duration in patients without contraindications to these high dose regimens.There are no data to support the use of IV amiodarone for acute conversion in patients with an ejection fraction of <40% or clinical heartCited by 5Publish Year 2002Author Richard S.SlavikIntravenous amiodarone pharmacology,pharmacokinetics Intravenous amiodarone is an effective,relatively safe antiarrhythmic for the treatment of recurrent,hemodynamically unstable VT/VF refractory to other drug therapy in the acute care setting.Intravenous amiodarone pharmacology,pharmacokinetics,and clinical use.Ann Pharmacother.
Cited by 6Publish Year 2005Author Panagiotis Korantzopoulos,Eugenia Pappa,Pavlos Karanikis,Evaggelos Kountouris,Vasiliki DimitroulInterventional Pharmacology Antiarrhythmics - The
GeneralDifferences Between Drugs Within The ClassAdministrationPharmacologic ActionIndications and ContraindicationsUndesirable EffectsWhat's The Evidence?A variety of arrhythmias may be encountered during coronary angiography and intervention.They can range in seriousness from premature complexes to potentially lethal ventricular fibrillation.Life-threatening arrhythmias occur in <1% of all cardiac catheterizations.If hemodynamically unstable ventricular tachycardia or fibrillation develops,the immediate treatment is electrical defibrillation.This may be supplemented by IV antiarrhythmic agents,such as amiodarone or lidocaine.See more on thecardiologyadvisorAmiodarone infusion in the treatment of acute atrial Jul 01,2005·Our results indicate superior efficacy with the higher dose of intravenous amiodarone for the routine treatment of acute atrial fibrillation or flutter in a coronary care unit setting.The divergence between the two groups after 10 hours suggests a sustained beneficial effect of prolonged high dose infusion as compared to low dose.Cited by 75Publish Year 1996Author M.S.S.ChowAmiodarone for pharmacological cardioversion of recent Amiodarone has been used both intravenously (i.v.) and orally for the pharmacological cardioversion of recent-onset atrial fibrillation.Intravenous amiodarone has been used as a bolus only or as a bolus followed by a continuous i.v.infusion until conversion or up to 24 h.Cited by 75Publish Year 1996Author M.S.S.ChowIntravenous Amiodarone Pharmacology,Pharmacokinetics Jun 01,1996·Available data suggest that intravenous amiodarone is associated with an efficacy rate of 50% or more in treatment-refractory VT/VF,and has a relatively rapid (224 h) onset of action.The drug is relatively well tolerated,but close hemodynamic,electrocardiographic,and
Cited by 9Publish Year 2004Author Ijaz A KhanFrontal plane QRST angle in the monitoring of intravenous
Dec 19,2020·Intravenous amiodarone infusion is effective and widely used treatment for pharmacological cardioversion of recentonset atrial fibrillation (Af).Although amiodarone may trigger various alterations in cardiac electrophysiology and electrocardiography (ECG),the impact of amiodarone treatment on frontal plane QRST angle remains unclear.Intravenous amiodarone for acute pharmacological May 21,2015·Atrial fibrillation (AF) is the most common arrhythmia seen in patients presenting to the emergency department (ED).Pharmacological conversion of atrial fibrillation to normal sinus rhythm (NSR) may be a feasible management strategy in selected patients.Recent guidelines have recommended intravenous amiodarone,a class III antiarrhythmic agent,for the conversion of AF toIntravenous amiodarone for ventricular arrhythmias intravenous (IV) amiodarone for acute treatment of recurrent and refractory ventricular tachycardia and ventricular fibrillation has been demonstrated in clinical trials.The ARREST trial,a randomized trial comparing IV amiodarone to placebo,found a significant improvement in
May 01,1985·International Journal of Cardiology,8 (1985) 67-76 67 Elsevier lJC 00251 Intravenous amiodarone in the acute termination of supraventricular arrhythmias P.Holt,J.C.P.Crick,D.W.Davies 1 and P.Curry Cardiology Department,Guy's Hospital,London,U K (Received 17 September 1984; revision accepted 9 November 1984) Holt P,Crick JCP,Davies DW,Curry P.Intravenous amiodarone in the acute Intravenous amiodarone pharmacology,pharmacokinetics,and clinical use.Intravenous amiodarone is an effective,relatively safe antiarrhythmic for the treatment of recurrent,hemodynamically unstable VT/VF refractory to other drug therapy in the acute care setting.Author:M.S.S.ChowCited by:75Publish Year:1996Intravenous amiodarone pharmacology,pharmacokinetics Was this helpful?People also askIs amiodarone an antiarrhythmic drug?Is amiodarone an antiarrhythmic drug?Amiodarone is a class III antiarrhythmic drug highly effective against a wide spectrum of ventricular tachyarrhythmias.We report an unusual case of acute liver and renal failure within 24 hours of initiation of intravenous (IV) amiodarone.Acute Liver and Renal Failure A Rare Adverse Effect Pharmacology in Emergency Medicine - EMCritrequire acute treatment with injectable drugs Objective There are many pharmacological options for the treatment of RAF (10,19,36).For most of these medications,clinical trials and external validity standard procedure for intravenous amiodarone or esmo-lol is explained in Table 7.
alternatives to amiodarone for seniorsside effects for amiodarone lungsgeneric name for amiodaronesubstitute for amiodaroneindications for amiodaroneamiodarone for v tachamiodarone for v fibamiodarone for afib rvrSome results are removed in response to a notice of local law requirement.For more information,please see here.12345NextSpecial Populations Hepatic Function ImpairmentAfter a single dose of amiodarone injection in cirrhotic patients,Cmax was significantly lower and average concentration values were seen for deseDosing Hepatic ImpairmentDosage adjustment is probably necessary in substantial hepatic impairment.No specific guidelines available.If hepatic enzymes exceed 3 times normExtemporaneously Prepared5 mg/mL Oral Suspension (ASHP Standard Concentration) (ASHP 2017)A 5 mg/mL oral suspension may be made with tablets and either a 1:1 mixture of OraDrugs for Conversion of Atrial Fibrillation - American TreatmentMechanismPathophysiologyPrognosisResearchRisksMedical usesUsesClinical significanceInteractionsMechanism of actionPharmacologyAdministrationSide effectsManagementSafetyResourcesAtrial fibrillation is the most common arrhythmia in patients visiting a primary care practice.Although many patients with atrial fibrillation experience relief of symptoms with control of the heart rate,some patients require restoration of sinus rhythm.External direct current (DC) cardioversion is the most effective means of converting atrial fibrillation to sinus rhythm.Pharmacologic cardioversion,although less effective,offers an alternativSee more on aafpCited by 13Publish Year 1998Author Joseph T.Dell'Orfano,Jerry C.Luck,Deborah L.Wolbrette,Hemantkumar Patel,Gerald V.NaccarelliUpToDateConversely,intravenous (IV) amiodarone begins to act within one hour,with rapid onset of action within minutes following an IV bolus.Estimates of the elimination half-life of amiodarone vary,depending on how the half-life has been measured and the route of amiodarone administration.dolus of i.v.amiodarone European Heart Journal Oxford Jul 28,2016·The best drug to use for pharmacological cardioversion of monomorphic ventricular tachycardia is often unclear.Amiodarone and procainamide have differing effects on the action potential,with more marked effects on activation and repolarization by procainamide.